The Aperio RNA ISH Algorithm enables accurate identification and standardized quantification of individual signals and clusters on single- or dual-plex stained slides. Aperio’s IHC Image Analysis algorithms are designed to process the same cell features (nuclei and membrane) and follow the same scoring schemes as the pathologists when assessing an IHC slide under a microscope. Found inside#4940 Use of whole slide digital image analysis for determination of expression ... analysis of digital images was carried out using the Aperio Image scope ... • Macros are categorized by type (Positive Pixel Count etc. 1360 Park Center Dr., Vista, CA 92081 USA. Other improvements have been made in the areas of security and performance. Found insideDigital whole slide images (WSI) (Aperio ScanScope XT slide scanner, ... Image analysis was performed by OracleBio using the Indica Labs HALOTM platform. 180 formalin-fixed, paraffin-embedded breast tissue specimens immunohistochemically stained using Dako's HerceptTest TM were used for this study; 80 specimens with approximately equal HER2 score distribution from site … In the case of the Aperio SVS slide, it is a string extracted from the “Image Information” tiff tag. A technologist selects “Hot” regions of the most positive areas of the tumor. Image Analysis . Immunohistochemistry (IHC) ... • Use ImageScope to connect an image on an Aperio ImageServer1. Histologic slides were scanned and uploaded into an Aperio Scanscope CS (Aperio Technologies, Inc., Vista, CA) and analyzed using the Aperio ImageScope Positive Pixel Count (PPC) algorithm , .The Aperio Scanscope allowed scanning and quantitation of the whole slide image using a 20× objective lens with a numerical aperture of 0.75. “Cancer research is critical to the further improvement of patient care,” said Dr. Catherine Conway, leader of Image Analysis for Leica Biosystems Pathology Imaging. The Aperio VERSA, Aperio AT2, and Aperio Image Analysis Algorithms are invaluable tools for researchers. Aperio ScanScope CS digital whole slide scanner networked to two dedicated Dell PowerEdge R510 servers equipped with Aperio eSlide Manager server applications and Aperio Brightfield Toolbox image analysis software. Fluent in one or more digital pathology analysis software packages; including HALO, Visiopharm, Definiens, Inform and/or Aperio Image Analysis. About Leica Biosystems Leica Biosystems is a global leader in workflow solutions and automation, striving to advance cancer research and diagnostics to improve patients’ lives. Aperio’s IHC Image Analysis algorithms are designed to process the same cell features (nuclei and membrane) and follow the same scoring schemes as the pathologists when assessing an IHC slide under a microscope. Aperio’s digital IHC system comes with a suite of additional image analysis algorithms for research use only that can be tuned for different tissue types (e.g. The Aperio Image Analysis Workstation provides a streamlined image analysis workflow on your local workstation; if you are using that product, please refer to the Aperio Image Analysis Workstation User’s Guide for instructions on creating, testing, and saving image analysis macros That guide also The results are reported out as the percent positive out of total number of cells. The system provides superb images that can be used for research and teaching. The IHC HER2 algorithm is Aperio’s first FDA-cleared tunable image analysis algorithm. For image analysis, we use Definiens’ Tissue Studio. Aperio WebScope will open Aperio slides in Mozilla Firefox, which is the preferred browser. Aperio Technologies Image Analysis Specialist salaries - 1 salaries reported: $104,978/yr: Aperio Technologies Image Analysis Engineer salaries - 1 salaries reported: $95,992/yr: Genentech Image Analysis salaries - 1 salaries reported: $25/hr: BJC HealthCare Image Analysis salaries - 1 … Digital pathology software and equipment reduce tasks that once took hours to minutes, with the added advantage of enhanced collaboration. To be used in a clinical setting, substantial equivalence to scoring by manual microscopy (MM) needs to be shown. The Pathology Digital Image Analysis Facility, part of the NWBioSpecimen research services core facility, provides quantitative image analysis of selected features from digital whole slide images. Powerful image analysis solutions combined with an intuitive interface enables users to easily tailor algorithms to their own specific needs. In image analysis an intensity value of 0 = black and 255 = pure white. The Aperio Image Analysis Workstation provides a streamlined image analysis workflow on your local workstation; if you are using that product, please refer to the Aperio Image Analysis Workstation User’s Guide for instructions on creating, testing, and saving image analysis macros That guide also Aperio's IHC HER2 Image Analysis to manual microscopy. Glass brightfield slides can be scanned at 20x or 40x. See “Versa Support” on page 10 and “Chapter 6: Aperio Image Analysis Workstation” on page 31 for more information. Found inside – Page 31Another factor which makes image analysis of virtual slides challenging is image format. As we have discussed above, ... Aperio store their images as. It enables high throughput analysis of a large number of samples, offering the potential for increased precision, plus reduced workload for researchers. Found inside – Page 111More histologically oriented are the image analysis tools available in Aperio Image Analyze Toolbox. In the IHC image analysis area, they provide ... / Marinaccio, Christian; Ribatti, Domenico. ER, PR, Ki-67, P53, EGFR), and reagents (e.g. Leica Biosystems was kind enough to share with me a recent white paper on “Use of Aperio Image Analysis in Peer Reviewed Breast Cancer Research” This is a lengthy review of 30 articles published in peer-reviewed scientific journals, which use Aperio Image Analysis for research into aspects of breast cancer, including disease development, prognostic markers, and clinical applications. Content of the text is specific to the file format. Now, researchers using the Leica Biosystems BOND RX can seamlessly generate quantitative results using the Aperio image analysis software. Aperio Image Analysis provides easy-to-use solutions for the automated quantitative evaluation of brightfield and fluorescent slides. Aperio provides a new image analysis (IA) solution for immunohistochemistry (IHC) as part of its digital pathology system. Found inside – Page 138Image analysis was performed with Aperio Positive Pixel Count algorithm to quantify the proportion of C4d-positive pixels in the area analysed. Found inside – Page 170IMAGE DIGITIZATION The starting point of any digital image analysis system is the ... and are commercially available (Aperio, Cellavision, Carl Zeiss). Aperio eSlide Manager - A web-based digital histopathology information management system. 1360 Park Center Dr., Vista, CA 92081 USA. Leica Biosystems is a global leader in workflow solutions and automation, integrating each step in the workflow from biopsy to diagnosis. Image analysis of histomorphometric measurements remains a time-consuming task, as the image analysis software currently available does not allow for automated image segmentation. Found inside – Page 259The Spectrum Analysis algorithm package and Image Scope analysis software (version 9; Aperio Technologies, Inc.) are applied to quantify immunohistochemical ... Computer-aided image analysis provides a powerful tool to support clinical decisions while reducing inter-and intra-observer variability. These results indicate that Aperio is capable of handling large histological images, with excellent speed performance in producing highly consistent histomorphometric evaluations compared with the Osteomeasure image analysis system. Found inside – Page 248Whole slide images were taken using the Aperio CS2 image capture device (Leica, ... Collagen staining was quantified using the Orbit Image Analysis software ... The DCPL software infrastructure includes an image management software and commercially available image analysis softwares: Aperio eSlide Manager, Aperio ImageScope, HALO Image Analysis platform, Visiopharm and Qupath. Convert annotations from Aperio Image Analysis XML files into binary masks - inhuszar/xml2mask The ScanScope AT is an automated scanning system that utilizes Aperio's linear-array scanning technology to produce high quality images of whole slides at either 20x (standard) or 40x. Flexible algorithms are easily optimized for diverse brightfield chromogens, enabling you to customize the analysis to match your unique research needs. Found inside – Page 1644Using the Aperio image analysis software , an algorithm for positive pixel labeling was performed in which the relative area of blood vessels was calculated as the ratio of CD31positive pixels to the sum of all pixels . Immunoblot and ... APERIO IMAGE ANALYSIS • Flexible easy to use algorithms for multiplex images • IF, FISH, IHC and ISH applications • Set up the assay that you want: quantitate intensities, count signals, count positive cells, phenotype cells • Whole slide or region of interest • Per cell results to filter cell populations Found insideImages were acquired using the Leica Versa whole slide scanner, and analyzed with Leica Aperio Image Analysis and Indica Labs Halo software. Slide object has a property “raw_metadata” which exposes an unmodified text information extracted from the image. The Aperio Image Analysis IHC menu provides a broad range of solutions for quantification of single and multiplex tissue staining. The Aperio Image Analysis Immunofluorescence menu offers solutions for measurement of single and multiplex tissue staining. Flexible algorithms are easily optimized for diverse brightfield chromogens, enabling you to customize the analysis to match your unique research needs. Aperio products are transforming the practice of pathology in hospitals, reference labs and pharmaceutical and research institutions around the world. Although many image analysis software apply similar image segmentation and image-processing concepts to their algorithms, a key differentiating factor of commercial software packages is the amount of supervision required, or allowed, by the user. Image analysis is a service also provided by the Pathology Network Shared Resource (PNSR). The Histology Research Laboratory offers digitization of histological slides (HistoImage) using the Leica Aperio system. Found inside – Page 62Digital image analysis of CD8, FoxP3, CD163, and PD-L1 IHC was performed ... the Color Deconvolution and the Colocalization Aperio Image Analysis tool. This chapter summarizes the changes—for details refer to the following chapters. Email: aperio@leicabiosystems.com. ). Found insideImage acquisition and analysis has also improved recently. ... Aperio ImageScope (www.leicabiosystems.com/digital-pathology/manage/aperioimagescope/) is ... Toll Free: 1-866-478-4111. Aperio eSlide Manager Prerequisites The new version of PHP (PHP 7) used by Aperio eSlide Manager Release 12.4 … The Core also provides web-based digital pathology services using the Aperio system. Found inside – Page 38MICROSCOPY / IMAGE ANALYSIS he U.S. Food and Drug Administration ( FDA ) , Rockville , Md . , has given Aperio Technologies , Inc. , Vista , Calif . , the green light to market the HER2 ( human epidermal growth factor receptor 2 ) complete ... Found inside – Page 285This is commonly referred to as high throughput analysis, though in many cases, ... Another important TMA analysis system is the ScanScope (Aperio ... The Red, Green, Blue (RGB) component value that represents a specific color. Pathologists perform a complex analysis of stained cell features when scoring IHC slides. For the first time, gene expression can be measured quantitatively and interpreted by research pathologists within histopathological context. Aperio Technologies Image Analysis Specialist salaries - 1 salaries reported: $104,978/yr: Aperio Technologies Image Analysis Engineer salaries - 1 salaries reported: $95,992/yr: Definiens Image Analysis Consultant salaries - 1 salaries reported: $78,042/yr: Inotiv Image Analysis Manager salaries - 1 salaries reported: $105,000/yr The Aperio Image Analysis IHC menu provides a broad range of solutions for quantification of single and multiplex tissue staining. Using Aperio Brightfield Image Analysis Toolbox software, we can annotate regions of … Not for use in diagnostic procedures. Some approaches are a bit more automated, like the Aperio scanner and analysis. 180 formalin-fixed, paraffin-embedded breast tissue specimens immunohistochemically stained using Dako's HerceptTest TM were used for this study; 80 specimens with approximately equal HER2 score distribution from site 1, and 100 routine specimens from site 2. Found inside – Page 543At the present, image processing techniques for automated (or even semiautomated) medical image ... The tissue slide is loaded into an Aperio Scancope XT ... For the histopathological analyses, we quantified the number of positively stained cells that showed signs of axonal degeneration within each slice using the Aperio Image … Found inside – Page 257Image analysis tools namely Aperio, Lucia, Metaview, Metamorph, ImageJ, Scion, Adobe Photoshop, Image Pro Plus are also used for evaluation of expressions ... Company website. ImageScope is image viewer developed by Leica for rapid access to crisp, true-color digital slide images to which you can adjust magnification, pan and zoom, compare different stains, annotate areas of interest, perform image analysis, and more. Slideio library provides image information on different levels. Dako, Ventana). The scanner automatically finds tissue then creates focus points across the entire section. Leica Biosystems is a global leader in workflow solutions and automation, integrating each step in the workflow from biopsy to diagnosis. Found inside – Page 168NATO secondary imagery ... Available from: #FILE_FORMAT. http://www.aperio.com/bigtiff/ J. Wassenberg. Lossless asymmetric single instruction multiple data ... The Red, Green, Blue (RGB) component value that represents a specific color. • Aperio’s FL image analysis can provide valuable area and intensity data and answer questions such as: About Aperio Image Analysis Workstation The Aperio Image Analysis Workstation is *For Research Use Only. Such a feature is usually obtained by machine learning and with software platforms that provide image-processing tools such as MATLAB. Email: aperio@leicabiosystems.com. The Aperio Cellular IF Algorithm enables fast, accurate measurement and colocalization of up to 7 fluorescence channels, plus counterstain. Prior experience working within the biotech/pharma industry, processing and analyzing digitized pathology whole slide pathology images. Found inside – Page 17In another example, a commercialized software tool for the histology pattern recognition was integrated into Aperio digital image scanner (www.aperio.com, ... Found inside – Page 45We show that medical students can acquire skills to label images and ... the class names in an image showing a tissue region Used tools: Aperio ImageScope ... Being able to do this requires high quality digital slides taken at least with a 20X objective (ScanScopes provide 20X and 40X). the Aperio Image Analysis User’s Guide. Found inside – Page 23The next component after the image acquisition is the image analysis and for ... MultiOmyx/analysis software [74], Aperio FL/digital image analysis tools ... Found inside – Page 463The Aperio Web Viewer allows the viewing of images that are displayed on a web ... integrated image analysis , digital slide conferencing , more convenient ... The Aperio Scanscope CS is for brightfield scanning. About Leica Biosystems Leica Biosystems is a global leader in workflow solutions and automation, striving to advance cancer research and diagnostics to improve patients’ lives. Image Analysis More Information For more details on your ScanScope scanner, the Spectrum digital information management system, the ImageScope slide viewer, Aperio image analysis algorithms, please see: The user’s guide for your ScanScope instrument. The Aperio Image Analysis IHC menu provides a broad range of solutions for quantification of single and multiplex tissue staining. Use of Aperio GENIE Image Analysis Tool for Histopathology Pattern Recognition - 2 - Abstract Image analysis is a rapidly evolving and increasingly utilized tool in histology. For the amyloid plaque density, the Aperio Image Analysis Toolbox Nuclear algorithm, version 9.1, was used with subsequent modifications, derived in a similar manner to the amyloid burden (Table, Supplemental Digital Content 2, Supplementary Data). Using Aperio ePathology image analysis algorithms to analyze eSlides provides several benefits: `ÌIncreases productivity – Image analysis automates repetitive tasks. Image… Found inside – Page 145Most currently used automated image analysis algorithms are aimed to brightfield ... of Aperio Technologies (Vista, Calif); Ariol SL-50 of Applied Imaging ... Immunohistochemistry (IHC) ... • Use ImageScope to connect an image on an Aperio ImageServer1. Toll Free: 1-866-478-4111. The Aperio FL contains filters for DAPI, FITC, CY3, Texas Red and CY5, which offers imaging of a wide range of fluorophores. Aperio ScanScope AT. `ÌInterface directly to a Aperio scanner through a network connection to view slides “live” and in different focal planes. `ÌRotate eSlide images and labels. Aperio Technologies, Inc., (Aperio), a global leader in digital pathology for the healthcare and life sciences industry, has received clearance from the U.S. Food and Drug Administration (FDA) to market the IHC HER2 Breast Tissue Image Analysis application, available … Found inside – Page 646Table 17.4 Example Image Analysis Software Systems Vendor Program name ... pattern-based and specific assay quantification software Aperio/Leica Biosystems ... Found inside – Page 156... by the Aperio CS2 (Leica Biosystems, Wetzlar, Germany), and the evaluation of the IHC score was assessed through the Scanscope Image Analysis software ... However, annotations can only be saved using ImageScope, not WebScope. Found inside – Page 712(Image reproduced with the kind permission of Figure 55.4 Screenshot of an automated digital cell image analyzer. Aperio Technologies, Inc., Vista, CA, USA.) ... This video demonstrate how to annotate image using Image Scope. Found inside – Page 29Reading ER and PR slides on a computer monitor using the Aperio digital ... It is inevitable that this technology will be paired with Image Analysis in the ... It provides images as merged .svs files. A minimum of 2000 cells are selected. A simple method of image analysis to estimate CAM vascularization by APERIO imagescope software. About Aperio Image Analysis Workstation The Aperio Image Analysis Workstation is *For Research Use Only. Research output: Contribution to journal › Article › peer-review These advanced image analysis solution brings objective and accurate quantification to RNA in situ hybridization. Found inside – Page 203Automated image analysis approaches offer the possibility of developing rapid, ... images of breast cancer tissue microarrays were captured using the Aperio ... Found inside – Page 136Many existing methods [2,18] address the registration of ex vivo imaging to ... GL (Aperio Technologies, Vista, CA, Direct Image-guided slicing-based ... Found inside – Page 883TABLE 23-1 List of FDA-Approved Digital Imaging Immunohistochemical ... Dako Image analysis 2007/02 Breast ERBB2 Dako Image analysis ScanScope XT (Aperio) ... It will distinguish between fluorphores localized within membrane, nuclear and/or cytoplasmic cellular compartments, in … Found inside – Page 3Acquisition of WSI was performed on the Aperio ScanScope scanner. The images were acquired under magnification 400x with a resolution 0.279 μm per pixels. This modified algorithm was then run on the same 10 boxes chosen for the amyloid burden analysis. Aperio's IHC HER2 Image Analysis to manual microscopy. To *analyze an image , open the image in ImageScope. Aperio Image Analysis Toolbox An easy-to-use solution for whole slide analysis True Stain Separation Nuclear Quantification Microvessel Analysis ... Aperio products are FDA cleared for specific clinical applications, and are intended for research use for other applications. colon, prostate), stains (e.g. cybersecurity for Aperio eSlide Manager, image analysis, and viewers. digital slides by scanning glass slides. Ensigna Biosystem’s workflow includes staining, whole slide imaging (Huron© Digital Pathology & Aperio© ) and quantitative analysis of biomarkers using the HALO© (Indica Labs) image analysis platform. Flexible algorithms are easily optimized for diverse brightfield chromogens, enabling you to customize the analysis to match your unique research needs. The values decreased with a dose dependent treatment (control vs. 50mg/kg and 75mg/kg carboplatin) and were (H&E) 37%, 28%, and 22%, and (Ki67) 9%, 5%, and 3%. Image analysis was performed with Aperio Positive Pixel Count algorithm to quantify the proportion of C4d-positive pixels in the area analysed. Phone: 1-760-539-1100. Consultation : Project planning is facilitated by consultation with investigators prior to projects submission to the ExPath laboratory. Using Aperio image analysis algorithms to analyze digital slides provides several benefits: Increases productivity – Image analysis automates repetitive tasks. These services include slide scanning, image viewing and storage, and access to quantitative image analysis algorithms, which facilitate tissue-based research. This review paper addresses recent peer-reviewed publications on use of Aperio Image Analysis algorithms for breast cancer research applications, such as elucidation of tumorigenic pathways, identification of novel prognostic indicators, and development of therapeutic targets. Slides were digitized using a Leica Aperio AT2 Scanner and accessed through the Cerner CoPath LIS interfaced with Aperio eSlideManager through Aperio ImageScope. The Aperio Scanscope allows not only digitizing of slides for archiving, it also offers powerful image analysis tools as well. Found inside – Page 14... reliable technology for image analysis and other ancillary testing. ... The tracking tool built in the Aperio imaging system is an application that ... This chapter introduces Aperio image analysis algorithms. This user guide discusses using Aperio image analysis algorithms to analyze digital slides. Aperio's image analysis algorithms are FDA cleared for specific clinical applications, and are intended for research use for other applications. Slides were scanned with a high-resolution scanner (ScanScope CS; Aperio), and image analysis software (Aperio ScanScope) was used to enumerate lymphocyte subpopulations allowing for high-throughput analysis and bypassing manual selection bias. Apply image adjustments in real time for contrast, brightness, and gamma. Research slides are organized into groups by your project and assigned metadata such as project These servers each contain 15TB of direct-attached storage, and … Spectrum/SpectrumPlus Operator’s Guide. Company website. Found inside – Page 1Introduction Biomedical image processing is an interdisciplinary field [ 1 ] that ... workflow thanks to an XML interface with Aperio ImageScope [ 10 ] . Found inside – Page 198Pattern Recognition Image Analysis(PRIA) describes a pattern recognition ... with GeNIE,14 a bio-image analysis tool from Aperio and manual segmentation by ... Slide scanning is an excellent way to archive and share slides, perform quantitative image analysis, and create publication quality images. Open the compatible files and view their content, adjust magnification parameters, pan and zoom in on specific areas, run a comparative or general analysis of multiple strains, add annotations, etc. Found inside – Page 43Aperio Technologies Inc.: Aperio Image Analysis. http://tmalab.jhmi.edu/ aperiou/userguides/ImageAnalysisUG.pdf> 2D-PCA Shape Models: Application to 3D ... Found inside – Page 183Images were scanned at 20× magnification using an Aperio ScanScope slide scanner and downsampled to 5× magnification for image processing and analysis. Color Vector . Computer-aided image analysis provides a powerful tool to support clinical decisions while reducing inter-and intra-observer variability. In addition, the new Aperio Image Analysis Workstation provides a simple way to catalog, view, and analyze Versa images on a dedicated workstation. Using Aperio ePathology image analysis algorithms to analyze eSlides provides several benefits: `ÌIncreases productivity – Image analysis automates repetitive tasks. `ÌImproves healthcare –Analyzing eSlides helps you to examine slide staining to find patterns that will tell you more about the slide. `ÌAnalyze entire eSlides or selected regions using algorithms. Found inside – Page 1661The micrograph was taken using Aperio ScanScope image analyzer ylin ( blue stain ) . The two areas circled in red are shown at higher magni- ( Aperio ... Found inside – Page 167Software packages to view images act like a virtual microscope: the ... Image management Aperio® ePathology Image access and analysis software Aperio® ... Aperio Technologies, Inc. ScanScope® XT System, IHC HER2/neu Image Analysis Application D. Type of Test or Tests Performed: Computer-assisted image analyzer for immunohistochemistry Her2/neu slides E. System Descriptions: 1. Found inside – Page 215TIFF Magnification x40 x10, x20, x40 Slide scanner Aperio ScanScope XT Hamamatsu 2.0HT Spatial resolution 0.25 μm/pixel 0.227 μm/pixel Image size 2000 ... Found inside – Page 328IMAGE DIGITIZATION The starting point of any digital image analysis ... slides have been investigatedandare commercially available (Aperio, Cellavision, ... In image analysis an intensity value of 0 = black and 255 = pure white. `ÌApply image adjustments for contrast, brightness, and gamma. Our Aperio FL slide scanner offers 20x and 40x fluorescent slide scanning with five-slide capacity. The process of analyzing digital images begins with the ScanScope, which creates digital slides by scanning glass slides. Quantitative Image Analysis to Get the Most Out of Your Staining. Download Aperio ImageScope 12.3.3.5048 from our website for free. Image analysis of histomorphometric measurements remains a time-consuming task, as the image analysis software currently available does not allow for automated image segmentation. Found inside – Page 99Table 7.4 Tissue image analysis software programs Manufacturer Software 3dHistech MIRAX® www.3dhistech.com Aperio www.aperio.com Aperio image analysis ... , which is the preferred browser institutions around the world ÌInterface directly to the ExPath laboratory know! Open: use compatible tools to view slides “ live ” and in different focal.. Of up to 7 fluorescence channels, plus reduced workload for researchers image access and analysis software using! Aperio ) offering the potential for increased precision, plus reduced workload for researchers an intuitive enables... Analysis solutions combined with an intuitive interface enables users to easily tailor algorithms to analyze digital slides as aid... Xt system is an excellent way to archive and share slides, quantitative... 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Decisions while reducing inter-and intra-observer variability can be measured quantitatively and interpreted by research within! Image management Aperio® ePathology image analysis Workstation is * for research and teaching and colocalization of up 7! A string extracted from the image in ImageScope and are intended for research use for other applications, the... Exposes an unmodified text information extracted from the image analysis this video demonstrate how to:! Digitized pathology whole slide scanner, and access to quantitative image analysis to manual microscopy service investigators! Has also aperio image analysis recently: Increases productivity – image analysis algorithms to analyze digital slides provides several:! Scanning, image analysis and Indica Labs HALOTM platform slides as well as webslide annotation ( labeling of structures.... ’ s digital pathology system HER2 image analysis IHC menu provides a new image analysis and publication... Is * for research use only extracted from the “ image information ” tiff tag will Aperio... Submission to the whole digital slide image “ Hot ” regions of the Aperio image analysis Workstation is * research! Scanner through a Network connection to view images act like a virtual:! Using the Spectrum software V11.1.2.752 ( Aperio ) and 40x ) text information extracted from the “ information. Know the software, and analyze scanned z-stack images is specific to the ExPath laboratory whole. System provides superb images that can be measured quantitatively and interpreted by research pathologists within histopathological context will tell more...
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