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Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Found insideLastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development. 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This book provides multidisciplinary reviews of the mechanism of action and uses of methotrexate in the treatment of cancer, psoriasis, gynecologic and inflammatory diseases. Found insideThe book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Examining free-shaped synthetic macromolecules, this guide reveals how dendrimers are used in a variety of scientific applications as a safer, more precise, and more effective way to practice medicine. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics. Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Found inside – Page iThis book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel ... The book discusses the prevention, diagnosis, treatment and follow-up of patients who have dangerous diseases. We hope this book will be a new approach to the immunotherapy of diseases and will improve public health and wellbeing. Found insideThis book deals with the biochemical and physiological characteristics of folic acid and examines how this important nutrient is absorbed and metabolized under different biological conditions. This book reviews the therapeutic developments in clinical trial design that have resulted in new treatment options for patients suffering from MS. Important ethical considerations that arise with the new treatments are included, as well as ... The book describes both the clinical and laboratory approaches to discovering the potentially adverse effects of cancer treatment on the ovary, also laying out possible preventative approaches and future directions for the field. Found insideThe aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights ... Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. Found insideFrom traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon ... A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Found inside – Page ivThis book comprehensively covers a range of challenging cases in dermatology. Helps you assess your knowledge and prepare for certification or recertification with about 800 review questions and answers throughout the book. Get state-of-the-art coverage of the full range of imaging techniques available to assist in the diagnosis and therapeutic management of rheumatic diseases. Guest edited by Andreas Reiff, topics include juvenile arthritis, juvenile spondyloarthritis, inflammatory bowel disease, vasculitis, scleroderma, eye conditions, and more Found insideThese volumes record the presentations made at the VIII International Symposium on Purine and Pyrimidine Metabolism in Manheld at Indiana University, Bloomington, USA from May 22- May 27, 1994. 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Zika Virus (ZIKV), which is associated with microcephaly and Guillain-Barré syndrome, brought a serious public health impact to most of Latin America countries in 2015 and 2016 during its endemic outbreak. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in ... This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Found inside – Page 1Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions ... Found insideAlthough many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. This text emphasizes the presentation, disease course, treatment and prognosis of the major conditions in the field, including: juvenile rheumatoid arthritis, spondyloarthropathy, juvenile dermatomyositis and scleroderma. The book could be a source of information for clinicians and researchers from different fields in raising awareness of the disease. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. 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